Papp-PAMPA (10-6) (cm/s) Papp-Caco-2(10-6) (cm/s)
Compound 6/7.4 7.4/7.4 6/7.4 7.4/7.4
Genistein 2.94 ± 0.49 1.50 ± 0.18 52.86 ± 3.77 37.75 ± 1.15
DHG 0.74 ± 0.18 0.39 ± 0.03 99.44 ± 0.48 55.47 ± 2.70
Daidzein 0.35 ± 0.04 0.45 ± 0.04 67.97 ± 2.76 40.64 ± 0.91
DHD 0.48 ± 0.06 0.21 ± 0.10 99.72 ± 3.76 52.78 ± 0.64
Data are presented as the mean ± S.D.
DHG, dihydrogenistein; DHD, dihydrodaidzein; PAMPA, artificial membrane permeation assay
Table 2: Effective permeability values in the presence (pH 6/7.4) and absence (pH 7.4/7.4) of a proton gradient across the Caco-2 cell monolayers and in the PAMPA model.