Drug Taken (µg mL-1) Intra-day (n=6) Inter-day (n=5) Recovery% Precision RSD%a Accuracy RE% Confidence  Limitb Recovery % Precision RSD%a Accuracy RE% Confidence  Limitb   GMF Method A 0.5 99.80 0.77 -0.20 0.499 ± 0.0004 99.60 0.83 -0.40 0.498 ± 0.004   1.0 99.90 0.94 -0.10 0.999 ± 0.010 100.10 1.58 0.10 1.001 ± 0.017   1.5 100.30 1.30 0.30 1.505 ± 0.021 100.50 1.84 0.50 1.508 ± 0.029 Method B 0.5 99.60 0.94 -0.40 0.498 ± 0.005 100.40 0.88 0.40 0.502 ± 0.005   1.0 99.80 1.25 -0.20 0.998 ± 0.013 99.90 1.36 0.10 0.999 ± 0.014   1.5 99.70 1.43 -0.30 1.496 ± 0.022 100.60 1.73 0.60 1.509 ± 0.027 Method C 1.0 100.20 0.89 0.2 1.002 ± 0.009 100.20 1.05 0.20 1.002 ± 0.011   2.0 99.70 1.16 -0.30 1.994 ± 0.024 100.10 1.39 0.10 2.002 ± 0.029   4.0 99.90 1.28 -0.10 3.996 ± 0.054 99.70 1.86 -0.30 3.988 ± 0.078   MXF Method A 0.5 100.60 0.73 0.60 0.503 ± 0.004 99.75 1.12 -0.25 0.499 ± 0.006   1.0 99.60 1.15 -0.40 0.996 ± 0.012 99.90 1.47 -0.10 0.999 ± 0.015   2.0 99.80 1.30 -0.20 1.996 ± 0.027 100.70 1.90 0.70 2.014 ± 0.040 Method B 1.0 100.30 0.87 0.30 1.003 ± 0.009 99.80 0.85 -0.20 0.998 ± 0.009   2.0 100.80 0.92 0.80 2.016 ± 0.019 100.30 1.40 0.30 2.006 ± 0.029   4.0 99.80 1.14 -0.20 3.992 ± 0.048 100.90 1.67 0.90 4.036 ± 0.071 Method C 0.5 99.60 0.96 -0.40 0.498 ± 0.005 100.20 0.93 0.20 0.501 ± 0.005   1.0 100.40 1.45 0.40 1.004 ± 0.015 99.90 1.20 -0.10 0.999 ± 0.013   2.0 100.20 1.56 0.20 2.004 ± 0.033 99.80 1.46 -0.20 1.996 ± 0.031 aRSD%, percentage relative standard deviation; R.E%, percentage relative error. bMean ± standard error.

Table 2: Evaluation of intra-day and inter-day precision and accuracy for the studied drugs obtained by the proposed methods.