Parameters Dual wavelength method Q-analysis method MCR method EXRSM method Reported HPLC **
ALP BENZ ALP BENZ ALP BENZ ALP BENZ ALP BENZ
Alloben® tabletsa (B.N.100251) 100.85± 1.131 98.02± 0.973 99.06± 1.275 99.67± 1.305 99.33± 1.190 98.47± 1.475 101.04± 1.261 98.72± 1.012 97.47± 1.250 97.70± 0.924
Standard additionb 99.45± 1.050 99.97± 1.286 98.05± 1.283 99.27± 1.137 98.53± 1.366 99.83± 0.927 99.11± 1.015 99.39± 0.795 98.36± 0.847 98.43± 1.281
F-test c 1.072(4.387) 1.846(4.875) 1.553(4.235) 1.795(4.228) 1.824(4.357) 1.254(4.208) 1.054(4.148) 2.234(4.526)  
Student’s t-test c 0.593 (2.160) 0.735(2.252) 0.813(2.228) 0.487(2.200) 1.147(2.146) 0.955(2.261) 1.342(2.323) 0.953(2.252)
a Average of six determinations.
b Average of 3 determinations.
c The values in the parenthesis are the corresponding theoretical values at р= 0.05.
**Reported RP-HPLC method using phosphate buffer PH: 4.0-acetonitrile-methanol (50:30:20v/v/v) as a mobile phase with UV detection at 250nm
Table 2: Determination of the studied drugs in the pharmaceutical preparations by the proposed methods and statistical comparison with reported HPLC method.