Parameters |
Dual wavelength method |
Q-analysis method |
MCR method |
EXRSM method |
Reported HPLC ** |
ALP |
BENZ |
ALP |
BENZ |
ALP |
BENZ |
ALP |
BENZ |
ALP |
BENZ |
Alloben® tabletsa (B.N.100251) |
100.85± 1.131 |
98.02± 0.973 |
99.06± 1.275 |
99.67± 1.305 |
99.33± 1.190 |
98.47± 1.475 |
101.04± 1.261 |
98.72± 1.012 |
97.47± 1.250 |
97.70± 0.924 |
Standard additionb |
99.45± 1.050 |
99.97± 1.286 |
98.05± 1.283 |
99.27± 1.137 |
98.53± 1.366 |
99.83± 0.927 |
99.11± 1.015 |
99.39± 0.795 |
98.36± 0.847 |
98.43± 1.281 |
F-test c |
1.072(4.387) |
1.846(4.875) |
1.553(4.235) |
1.795(4.228) |
1.824(4.357) |
1.254(4.208) |
1.054(4.148) |
2.234(4.526) |
|
Student’s t-test c |
0.593 (2.160) |
0.735(2.252) |
0.813(2.228) |
0.487(2.200) |
1.147(2.146) |
0.955(2.261) |
1.342(2.323) |
0.953(2.252) |
|
a Average of six determinations.
b Average of 3 determinations.
c The values in the parenthesis are the corresponding theoretical values at р= 0.05.
**Reported RP-HPLC method using phosphate buffer PH: 4.0-acetonitrile-methanol (50:30:20v/v/v) as a mobile phase with UV detection at 250nm |
Table 2: Determination of the studied drugs in the pharmaceutical preparations by the proposed methods and statistical comparison with reported HPLC method. |