S.No Chemical and Physical Treatments to Promote 1 Aggregation 2 Fragmentation 3 Precipitation 4 Dephosphorylation 5 Deamidation 6 Deglycosylation 7 Hydrolysis             8 Oxidation 9 Disulfide bond exchange 10 Ligand release

Table 5: Purposeful (forced) degradation of biotechnology products.