| Category |
Guidelines |
| Molecular imprinted receptor strategy |
The scientific design for the implement of bioanalogous recognition abilities into a material to elucidate the forces that control guest interactions. |
| Design and creation of a recognition cavity is especially important, to implement the functionality of necessary stereochemical feature in artificial materials, and the discriminatory capacity of the specific sites. |
| The chemical engineering design of recognition system influences on the physicochemical properties of re-uptake and release of the initial stereoisomer template in a polymeric environment are needed to overcome for limitations. |
| The generating MIP material to achieve appropriate orientation at a catalytic of appropriately aligning with either the active or stabilization domain, yet rotational position and assist to pinhole compounds of different molecular entities but sharing a common target. |
Parameters for chiral recognition by MIP-based matrix relate to: resolution, control of release and the robustness of the designed systems.
The ability to discriminate chirally by an imprinted chiral agent is complementary principles concern the charge distribution at the interface of the interacting molecules and the spatial structural arrangement. |
| Tighter binding (higher affinity, K) between one enantiomer and the functional monomer might be a source of reduced mass transfer and thus a slightly higher mobility of the complex. |
| The selectivity maximum to a higher concentration of the selective site when the template-MIP complex was decreasing, conferring to the absence of a differentiable maximum value at finite concentrations when the effects of association of the template species or the bound MIP were zero. |
| The biomaterials and self-assembly of the complementary functional groups by polymerizing monomeric components containing a given template into a confined entity as a result of direct the generation of organized functional structures in equilibrium conditions. |
| The creating molecular recognition in material, where combined approach to the use of a material can selectively recognize and respond to variations in the analyte concentrations and trigger a controlled level of active determined by this molecular recognition event. |
| The mechanisms, of the extent and consequences of receptor co-localization and inter-receptor communication may significantly enhanced the understanding how a protein receptor and enzyme activity in their skin and elicit luminescence or fluorescence |
| The presence of the fluorescent MIPs having a fluorophore stemming in the imprinted cavities make them amenable to mechanistic scrutiny by fluorescence spectroscopic techniques could be visualize through skin. |
| Growing the nano level to the meso level and the macro level with internal structural organization for MIP nanostructure incorporating within support membrane, template binding to imprinted sites can either change the pore network, therefore altering membrane permeability. |
| A certain thickness of membrane for optimizing the process and mismatching of the membrane perturbation energy that will not affect the functionalization of the selective materials. And, the chiral molecularly imprinted microspheres are shown to have distinctly different responses, and alterations of the cell surface in addition to those obtained by adding the parent compounds. |
| For stereoselective and trans-membrane transport The rationale for designing the binding agents involves the therapeutic effect of its administration arises from an increase in the plasma concentration in body compartments and this increase is fostered by the desired enantiomer found in plasma that can diffuse into fluid. |
| Characterization of recognition ability of MIPs |
Nuclear magnetic resonance (NMR) |
| Fourier transform Infrared spectroscopy (FT-IR) |
| Fluorescence spectroscopy |