Figure 2: Differential responses of uterine sarcoma cell variants MES-SA, MES-SA/DX5, and MES-SA/DX5v. Cell survival following 24 h incubation with a serial of Dox concentrations (A). Expression of P-gp under culture conditions (B). Cell survival following 24 h incubation with a serial of sanazole concentrations (C). Sanazole cytotoxicity is independent from P-gp expression in MES-SA/DX5 and MES-SA/X5v cells. Data presented is the average ± SEM of at least 3 independent replicates.