Commercial product UPLC method Derivative SFS FDSFS Reference methodb Meana ± SD 99.75 ± 0.93 98.66 ± 0.86 99.29 ± 1.54 t-test 0.77 0.83 2.23c F-value 2.74 3.21 6.2c aMean of seven and five determination of the proposed and reference methods bAn HPLC method using a C8 column with methanol: 50 mM KH2PO4 buffer pH 6.8 (80:20 v/v) as mobile phase, UV detection at 270 nm (25) cThe theoretical values of t and F at P=0.05

Table 6: Statistical comparison between the proposed UPLC and the reference method for the determination of atomoxetine HCl in Strattera® capsules.