| Strategies in surface chemistry |
Details |
References |
| Nanoparticle conjugation |
•Functional groups directly bonded to nanoparticle surface or,
•Facilitated by catalyst.
|
[104] |
| Click chemistry |
•Specific conjugation at desired location (due to azide & alkyne reactive groups)
•Useful where orientation & stability of moiety is important.
|
[105] |
| Linker chemistry |
Linker provides a control over molecular orientation and useful for controlled delivery systems |
[106] |
| Electrostatic interactions |
Cationic-anionic interactions |
[107] |
| Hydrophilic/hydrophobic interactions |
Nanoparticle’s surface engineered with hydrophobic surface which can adsorb hydrophobic drugs. |
[106] |
| Affinity interactions |
Surface modified with streptavidin for specific bioconjugation. |
[109] |