Figure 8: (a) Topical use of tamoxifen applied on the dorsal skin of rabbits after exposure times of 1, 2, 3, and 6 days. Blood samples were collected from the ears, and were analyzed using HPLC, showing successively increased tamoxifen concentration in the blood. (b) Topical use of the combination of phytonutrients applied on the dorsal skin of rabbits that exposure for 1 and 4 days respectively and then collected for analysis were blood from ears, and were send for analysis by HPLC. The results showed the components from the combination of phytonutrients in the blood successively increased.