Ref number Authors Candidates medications Report
  Year published   style
38 Fujimori S (2011) Rebamipide CS
39 Mizukami K (2011) Rebamipide CS
37 Kurokawa S (2013) Rebamipide CS
40 Fujimori S (2010) Rebamipide and misoprostol CS
41 Watanabe T (2008) misoprostol CS
43 Arakawa T (2012) prostaglandin derivatives, mucoprotective drugs, probiotics, and mitochondrial protective drugs A
42 Takeuchi K (2010) Endogenous PGE(2) A
45 Higuchi K (2009) Lansoprazole A
44 Yoda Y (2010) Lansoprazole A
47 Lim YJ (2012) PPIs: no small bowel protective effect A
46 Zhang S (2013) Omeprazole and pantoprazole cannot protect the small intestine from the damage induced by diclofenac A
48 Amagase K  (2010) Lafutidine (histamine H(2) receptor antagonist with a mucosal protective action) A
49 Umegaki E (2010) Roxatidine (H(2) receptor antagonist) A
50 Satoh H (2012) Inhibition of acid secretion by antisecretory drugs may exacerbate NSAID-induced intestinal lesions A
51 Guslandi M (2012) probiotics CS
52 Satoh H (2010) Soluble dietary fibers A
53 Satoh H (2010) Insoluble dietary fiber and soluble dietary fiber A
54 Sivalingam N (2011) Zinc A
55 Rodríguez de la Serna A (1994) Zinc acexamate CS
57 Wallace JL (1994) NO-releasing NSAID A
56 Takeuchi K (2007) Endogenous NO A
3 Lim YJ (2012) Selective COX-2 inhibitors (coxibs) A
58 Maehata Y (2012) Selective COX-2 inhibitors are not completely safe for the small bowel CS
59 Fukumoto K (2011) TNF-α A
60 LoGuidice A (2012) bacterial β-D-glucuronidase A
61 LoGuidice A (2010) Mitochondrial cyclophilin D A
62 Kawahara R (2011) α7 nicotinic acetylcholine receptors A
63 Shiotani A (2010) geranylgeranylacetone CS
64 Iwai T (2011) Geranylgeranylacetone A
33 Higashiyama M (2012) cilostazol (specific phosphodiesterase (PDE)-3 inhibitor) A
65 Kato N (2009) Sildenafil (inhibitor of phosphodiesterase subtype 5) A
66 Yasuda M (2011) Dopamine D2-receptor antagonists A
67 Yanaka A (2013) Sulforaphane CL
68 Menozzi A (2010) K(ATP) channel opener diazoxide A
69 Marchbank T (2008) Natural bioactive products (nutriceuticals), such as fish hydrolysates CS
70 Amagase K (2012) Monosodium glutamate A
71 Chao G (2012) Muscovite (natural clay consisting of an insoluble double silicate of aluminum and magnesium) diclofenac A
72 Davies NM (1997) tempo (nitroxide stable free radical scavenger) and metronidazole A
NO: Nitric oxide
COX-2: Cyclooxygenase-2
CS: Clinical study
CR: Case report
A: Animal study
CL: Cell line
Table 3: Prevention and therapy of Non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury.