| Drug name |
Recovery ± SD |
Calculated
t- values |
Calculated
F- values |
| Proposed methods |
Reference method |
|
| Exforge® |
Aml. (%) |
95.81± 0.83 |
95.79 ± 0.65 [26] |
0.06 |
1.64 |
| Val. (%) |
97.46 ± 0.49 |
97.09 ± 0.51[26] |
1.04 |
0.92 |
Losar
Mepha®
Ator® |
Los. (%) |
101.15 ± 0.95 |
101.10 ± 0.45 [21] |
0.11 |
4.54 |
| Ator. (%) |
99.98 ± 1.35 |
100.65 ± 1.34 [21] |
0.91 |
1.02 |
| Caduet ® |
Aml. (%) |
96.70 ± 0.61 |
96.68 ± 0.63 [22] |
0.05 |
0.92 |
| Ator. (%) |
96.41 ± 0.26 |
96.93 ± 0.36 [22] |
2.26 |
0.54 |
|
| (Where the Tabulated t-values and F -ratios at p=0.05 are 2.57 and 5.05)[21,22,26] are the reference numbers of reported method used in the comparison |
| Table 6: Statistical comparison of the proposed and published methods for determination of Amlodipine besylate, Losartan potassium, Valsartan and Atorvastatin calcium respectively in their dosage forms by reported method (Tstudent test) and (F–test for variance). |