I- Standard addition methoda III- Potentiometric titrations
  Pure solutions Plavix tablets
Taken (mg) Recovery (%) R.S.D.% Taken (mg) Recovery (%) R.S.D.% Recovery (%) R.S.D.%
Pure solutions STA as titrant  
2.1 99.1 0.63 6.3 99.6 0.50 98.5 0.65
4.2 99.3 0.55 8.4 99.1 0.77 98.1 1.41
6.3 99.0 0.81 12.6 99.0 0.89 98.0 1.08
8.4 98.2 0.64 21.0 98.2 0.99 97.3 0.97
Plavix tablets PTA as titrant    
2.1 99.0 0.22 4.2 99.3 0.77 99.0 1.05
4.2 98.9 0.48 12.6 98.7 0.59 98.6 1.04
6.3 98.0 0.51 21.0 98.0 0.47 98.5 1.18
II- Calibration curve method 29.4 98.0 0.68 98.2 0.96
6.3 99.3   42.0 97.6 0.78 97.0 1.44
8.4 98.6   SMA as titrant  
12.6 98.0   2.1 99.7 0.44 99.0 0.85
Plavix tablets 4.2 99.3 0.67 99.4 0.64
2.1 98.4   6.3 99.0 0.78 98.6 0.84
4.2 98.5   8.4 98.5 0.51 98.0 0.77
6.3 98.7   12.6 98.3 0.73 98.2 1.11
Spiked urinea 29.4 98.0 0.80 97.0 1.23
2.1 99.0 0.21 PMA as titrant  
4.2 98.6 0.24 4.2 99.8 0.16 99.5 0.84
6.3 98.3 0.43 6.3 99.4 0.77 99.3 0.26
Spiked human seruma 8.4 99.0 0.78 99.1 0.65
2.1 98.3 0.67 12.6 98.5 0.58 98.5 0.91
4.2 98.0 0.48 29.4 98.0 0.88 98.0 0.38
6.3 97.6 1.09 42.0 98.3 0.30 97.8 0.69
Table 5: Determination of clopidogrel bisulfate in bulk solutions, tablet,urine and serum applying the standard addition method, calibration curve method and potentiometric titrations using CLO-ST/CMCPE.