I- Standard addition method
a
III- Potentiometric titrations
Pure solutions
Plavix tablets
Taken (mg)
Recovery (%)
R.S.D.%
Taken (mg)
Recovery (%)
R.S.D.%
Recovery (%)
R.S.D.%
Pure solutions
STA as titrant
2.1
99.1
0.63
6.3
99.6
0.50
98.5
0.65
4.2
99.3
0.55
8.4
99.1
0.77
98.1
1.41
6.3
99.0
0.81
12.6
99.0
0.89
98.0
1.08
8.4
98.2
0.64
21.0
98.2
0.99
97.3
0.97
Plavix tablets
PTA as titrant
2.1
99.0
0.22
4.2
99.3
0.77
99.0
1.05
4.2
98.9
0.48
12.6
98.7
0.59
98.6
1.04
6.3
98.0
0.51
21.0
98.0
0.47
98.5
1.18
II- Calibration curve method
29.4
98.0
0.68
98.2
0.96
6.3
99.3
42.0
97.6
0.78
97.0
1.44
8.4
98.6
SMA as titrant
12.6
98.0
2.1
99.7
0.44
99.0
0.85
Plavix tablets
4.2
99.3
0.67
99.4
0.64
2.1
98.4
6.3
99.0
0.78
98.6
0.84
4.2
98.5
8.4
98.5
0.51
98.0
0.77
6.3
98.7
12.6
98.3
0.73
98.2
1.11
Spiked urine
a
29.4
98.0
0.80
97.0
1.23
2.1
99.0
0.21
PMA as titrant
4.2
98.6
0.24
4.2
99.8
0.16
99.5
0.84
6.3
98.3
0.43
6.3
99.4
0.77
99.3
0.26
Spiked human serum
a
8.4
99.0
0.78
99.1
0.65
2.1
98.3
0.67
12.6
98.5
0.58
98.5
0.91
4.2
98.0
0.48
29.4
98.0
0.88
98.0
0.38
6.3
97.6
1.09
42.0
98.3
0.30
97.8
0.69
Table 5:
Determination of clopidogrel bisulfate in bulk solutions, tablet,urine and serum applying the standard addition method, calibration curve method and potentiometric titrations using CLO-ST/CMCPE.