Raspberry ketone St John’s wort   Treated (n=5) Control (n=5) SJW (n=5) Control (n=5) CLoral (mL/min) 115±12 107±5 184±6.2* 114±40 MRT(min) 50±3 49±1 52±1 53±9 Vd / F (L/kg) 5.7±0.3 5.3±0.2 9.6±0.2 6.2±3.0

All of data were shown as mean ± S.D.

CLoral : oral clearance rate; MRT: mean residence time; Vd: volume of distribution;

F: bioavailability; SJW: St John’s wort

*Statistically significant difference from control (Welch’s t-test, P<0.05)

Table 1: Pharmacokinetic parameters of midazolam.