Raspberry ketone St John’s wort
  Treated
(n=5)
Control
(n=5)
SJW
(n=5)
Control
(n=5)
CLoral (mL/min) 115±12 107±5 184±6.2* 114±40
MRT(min) 50±3 49±1 52±1 53±9
Vd / F (L/kg) 5.7±0.3 5.3±0.2 9.6±0.2 6.2±3.0
All of data were shown as mean ± S.D.
CLoral : oral clearance rate; MRT: mean residence time; Vd: volume of distribution;
F: bioavailability; SJW: St John’s wort
*Statistically significant difference from control (Welch’s t-test, P<0.05)
Table 1: Pharmacokinetic parameters of midazolam.