Variable IA-BioHA (n=291)   Mean (SD) ES* % with ≥3-point improvement PF 4.77 (9.65) 0.49 51.8 RP 4.13 (10.49) 0.39 49.8 BP 3.85 (9.93) 0.39 53.7 GH 1.38 (6.22) 0.22 35.0 PCS 4.55 (8.50) 0.54 54.5

*Computed as mean/SD. BP, bodily pain; ES, effect size; GH, general health perceptions; PCS, physical component summary; PF, physical functioning; RP, role limitations due to physical health.

Table 1: Change from baseline (week 0) in ES in the physical health domains of SF-36 scores for the IA-BioHA treatment group at week 26