SF-36 scale Weeknumber Least squared mean of change scores from baseline
(week 0)
Difference (SE) P value
PF 26 4.73 0.03 (0.54) 0.955
  52 4.76    
RP 26 4.01 0.37 (0.63) 0.561
  52 4.38    
BP 26 3.79 1.61 (0.65) 0.014
  52 5.40    
GH 26 1.37 0.35 (0.46) 0.441
  52 1.72    
VT 26 2.44 0.59 (0.54) 0.274
  52 3.03    
SF 26 2.06 0.33 (0.64) 0.609
  52 2.38    
RE 26 1.06 0.47 (0.76) 0.539
  52 1.53    
MH 26 1.78 0.45 (0.57) 0.428
  52 2.23    
PCS 26 4.38 0.64 (0.52) 0.219
  52 5.02    
MCS 26 0.50 0.35 (0.57) 0.545
  52 0.85    
BP: bodily pain; GH: general health perceptions; MCS: mental component summary; MH: mental health; PCS: physical component summary; PF: physical functioning; RE: role limitations due to emotional problems; RP: role limitations due to physical health; SE: standard error; SF: social functioning; VT: vitality.
Table 2: Comparisons of the SF-36 change scores at weeks 26 and 52 in patients who received IA-BioHA during the FLEXX Trial and a repeat series of IA-BioHA in the Extension Study.