Run ACN Flow   rate (ml) pH Area Retention time Capacity factor
Actual value (Mean ± SD) (n=3) Predicted value Actual value (Mean ± SD) (n=3) Predicted value Actual value (Mean ± SD) (n=3) Predicted value
1 80.00 0.80 7.00 401423 ± 6248 401603 4.03 ± 0.062 4.01 2.36 ± 0.036 2.37
2 80.00 1.00 6.00 422691 ± 6023 423410 3.68 ± 0.052 3.69 2.05 ± 0.031 2.06
3 90.00 1.00 5.00 378411 ± 6157 379013 5.13 ± 0.065 5.11 3.24 ± 0.051 3.24
4 90.00 1.20 6.00 349467 ± 4529 349119 4.48 ± 0.061 4.50 2.73 ± 0.044 2.74
5 90.00 0.80 6.00 359129 ± 5488 359312 4.62 ± 0.064 4.63 2.84 ± 0.041 2.85
6 90.00 1.00 7.00 427143 ± 6759 426804 4.52 ± 0.066 4.51 2.78 ± 0.043 2.79
7 70.00 0.80 6.00 285321 ± 4581 285711 3.74 ± 0.051 3.72 2.11 ± 0.029 2.12
8 80.00 1.00 6.00 422658 ± 6589 423407 3.68 ± 0.058 3.69 2.06 ± 0.029 2.06
9 70.00 1.00 5.00 378854 ± 6772 379209 3.43 ± 0.054 3.44 1.84 ± 0.025 1.85
10 80.00 0.80 5.00 412894 ± 7025 412217 4.09 ± 0.056 4.07 2.41 ± 0.037 2.43
11 80.00 1.00 6.00 424759 ± 6855 423434 3.69 ± 0.055 3.68 2.07 ± 0.027 2.06
12 80.00 1.20 7.00 401267 ± 5496 402006 3.72 ± 0.061 3.71 2.15 ± 0.031 2.15
13 70.00 1.00 7.00 305821 ± 3544 305308 4.03 ± 0.049 4.01 2.35 ± 0.033 2.36
14 80.00 1.20 5.00 417741 ± 6554 417510 3.69 ± 0.052 3.68 2.07 ± 0.027 2.08
15 70.00 1.20 6.00 301623 ± 3624 301505 3.17 ± 0.039 3.18 1.65 ± 0.021 1.66
Table1: Observed values of responses for Box–Behnken design (Design Expert 8.0.7.1).