Pharmacokinetic parameters
Lacidipine oral suspension
Lacidipine transdermal niosomal gel
AUC
0-t
(ng.h./mL)
976.45 ± 126.43
2500.135 ± 137.87
C
max
(ng/mL)
104.37 ± 37.95
131.45 ± 22.87
T
max
(h)
4.00 ± 0.12
8.00 ± 0.17
Half life (h)
7.2285 ± 0.16
24.18448 ± 0.23
Elimination rate constant
0.114739
0.060862
AUC
0-inf
(ng.h./mL)
1051.059 ± 123.34
2693.358 ± 130.25
AUMC
0-t
(ng.h./mL)
7612.35 ± 121.65
39524.4 ± 128.97
AUMC
0-inf
(ng.h./mL)
10053.06 ± 118.87
51973.86 ± 132.98
Table 9:
Pharmacokinetic parameter of lacidipine oral suspension and transdermal niosomal gel, values represented are mean ± SD (n=6).