Pharmacokinetic parameters Lacidipine oral suspension Lacidipine transdermal niosomal gel
AUC0-t (ng.h./mL) 976.45 ± 126.43 2500.135 ± 137.87
Cmax (ng/mL) 104.37 ± 37.95 131.45 ± 22.87
Tmax (h) 4.00 ± 0.12 8.00 ± 0.17
Half life (h) 7.2285 ± 0.16 24.18448 ± 0.23
Elimination rate constant 0.114739 0.060862
AUC0-inf  (ng.h./mL) 1051.059 ± 123.34 2693.358 ± 130.25
AUMC0-t (ng.h./mL) 7612.35 ± 121.65 39524.4 ± 128.97
AUMC0-inf (ng.h./mL) 10053.06 ± 118.87 51973.86 ± 132.98
Table 9: Pharmacokinetic parameter of lacidipine oral suspension and transdermal niosomal gel, values represented are mean ± SD (n=6).