 |
| Figure 6: Typical HPLC chromatograms obtained from 20 μl injections
of Amlodipine Besylate Amlodipine impurity A, B, Atorvastatin Calcium,
Atorvastatin impurity A and C under chromatographic conditions of mobile
phase consisted of acetonitrile: phosphate buffer (PH = 6.5) was pumped
on columns at a flow rate 1.2 ml/min and detected at 240 nm at constant
temperature 40°C. (Ascending order) 1- Agilent eclipse plus C18 (3.5 um, 4.6 x 100 mm) and acetonitrile 30% 2- Agilent eclipse plus C18 (3.5 um, 4.6 x 100 mm) and acetonitrile 35% 3- Thermo BDS HYPERSIL C18 (5um, 150 X 4.6 mm) and acetonitrile 30% 4- Thermo BDS HYPERSIL C18 (5um, 150 X 4.6 mm) and acetonitrile 35% |