item Absorbance
Subtraction
Amplitude
Modulation
Extended
Ratio
Subtraction
Chemometric Reported**
method
MOX HCT
Drug MOX HCT MOX HCT MOX HCT PLS PCR PLS PCR MOX HCT
Mean 99.98 100.20 99.92 100.09 100.10 99.91 100.46 100.43 100.33 100.34 99.37 100.83
S.D 0.526 0.563 0.519 0.529 0.706 0.670 0.722 0.805 0.729 0.666 1.245 1.321
R.S.D% 0.526 0.562 0.519 0.529 0.705 0.671 0.719 0.802 0.727 0.664 1.253 1.310
n 5 5 5 5 5 5 8 8 8 8 5 5
Variance 0.277 0.317 0.269 0.280 0.498 0.449 0.521 0.648 0.531 0.444 1.550 1.745
StudentĀ“s 1.01 0.981 0.912 1.164 1.141 1.390 1.781 1.696 0.776 0.770    
t-test * (2.306)* (2.306) (2.306) (2.306) (2.306) (2.306) (2.201) (2.201) (2.201) (2.201) - -
F-value* 5.596 5.505 5.762 6.232 3.112 3.886 2.975 2.392 3.286 3.930    
  (6.39)* (6.39) (6.39) (6.39) (6.39) (6.39 (6.09)* (6.09) (6.09) (6.09) - -
*Average of three determinations
** Corresponding to their ratio in pharmaceutical formulation
Table 7: Results obtained for the analysis of binary mixtures of MOX and (validation set) by the multivariate spectral analysis methods.