Samples Drug Conc. SAS Particle Size (nm) ΔHf (J/g) Dissolution (%) K(h-1) R2
Original SLM
-
15,970 175.2 21.9 ± 2.2 0.058 0.84
1 5 1:10 670.8 99.3 78.2 ± 4.1 0.345 0.85
2 5 1:15 590.7 95.6 80.5 ± 3.9 0.358 0.84
3 5 1:20 350.2 74.8 95.2 ± 3.2 0.646 0.900
4 10 1:20 465.0 81.2 93.6 ± 3.8 0.604 0.93
5 15 1:20 530.4 88.5 90.3 ± 3.3 0.518 0.94

Original HSP
-

34,000 302.0 4.72 ± 1.0 0.011 0.71
1 5 1:10 890.3 240.6 60.0 ± 3.0 0.218 0.74
2 5 1:15 720.6 190.1 75.6 ± 3.1 0.325 0.71
3 5 1:20 450.2 147.9 90.0 ± 3.2 0.516 0.79
4 10 1:20 545.4 140.1 85.9 ± 3.0 0.443 0.75
5 15 1:20 600.7 137.7 84.0 ± 2.9 0.417 0.73
Original GLB
-
111,200 287.0 10.9 ± 2.0 0.027 0.85
1 5 1:10 226.0 165.2 83.6 ± 4.2 0.462 0.96
2 5 1:15 185.2 110.9 90.0 ± 4.5 0.605 0.95
3 5 1:20 120.0 84.6 99.6 ± 4.0 1.345 0.991.007
4 10 1:20 140.3 93.7 98.1 ± 2.2 1.007 0.99
5 15 1:20 150.1 99.1 96.3 ± 3.2 0.845 0.98
Table 1: Preparation parameters namely drug concentration (mg/ml) and solvent to antisolvent ratio (SAS), and properties like mean particle size, melting enthalpy (ΔHf) and the dissolution parameters: percent dissolution (at 4 hours), dissolution rate constant K(h-1) and the correlation coefficient R2 of the original drugs (SLM, HSP and GLB) and their nanoparticles prepared by EPN.