Parameter Transdermal administration Intravenous administration*
Cmax(μg/ml) 0.56 0.52
tmax(h) 3.00 0.083
T1/2α(h) 0.37 0.067 ± 0.052
T1/2β(h) 11.85 0.6617 ± 0.268
CLt(L h-1) 1.08 0.69 ± 0.21
AUC0-t(μg ml-1h) 8.34 --
*Data from [27].
Table 2: Comparison of MDZ pharmacokinetics between Transdermal administration and Intravenous administration in rats.