Parameter
Transdermal administration
Intravenous administration*
C
max
(μg/ml)
0.56
0.52
t
max
(h)
3.00
0.083
T
1/2α
(h)
0.37
0.067 ± 0.052
T
1/2β
(h)
11.85
0.6617 ± 0.268
CL
t
(L h
-1
)
1.08
0.69 ± 0.21
AUC
0-t
(μg ml
-1
h)
8.34
--
*Data from [27].
Table 2:
Comparison of MDZ pharmacokinetics between Transdermal administration and Intravenous administration in rats.