Sample Time (min.) Chemical shift
(ppm)
Analytical samplesa  5 15.42 ±0.02
15 15.40 ±0.01
30 15.40 ±0.01
60 15.40 ±0.02
180 15.44 ±0.02
360 15.44 ±0.01
Calibration samplesb 15.40 ±0.04
a Results are expressed as the mean ± S.D. (n=3).
b The triplicate measurements were carried out at five suitable concentrations of
19F-TP for the preparation of the calibration curve. Results are expressed as the mean ± S.D. calculated from the total calibration samples (n=15).
Table 3: Chemical shift of the 19F NMR signal of 19F-TP in Small-LNEs in mice
blood for analytical and calibration samples.