Figure 1: Main pathogenic mechanisms behind neurodegeneration. The grey area corresponds to a feedback and synergy zone. The homeostatic activity of endocannabinoids and their receptors is defined within this zone. The alleged neuroprotective activity of phytocannabinoids, such as CBD and THC or its combination, should find the right dose to produce the desired effect. The type and state of activity of their receptors as well as the level of cell damage are factors worth to consider.(the original illustration is attached in .tiff and eps format).