Figure 6: Effect of dispersions containing CLZ nanoparticles on retinal vascularcaliber in rats injected with ET-1. Rat eyes were instilled with 30 μl of dispersionscontaining CLZ microparticles (CLZmicro) or nanoparticles (CLZnano), and retinalvasoconstriction of the right eye was caused by the intravitreal injection of ET-1.RVC (%) was monitored using a Digital Microscope, and calculated accordingto Eq. 4 (see Materials and methods). The data are presented as the means± S.E. of 6 independent experiments. *1P < 0.05, vs. saline. *2P < 0.05, vs.CLZmicro.