Formulation Content (w/v%) Treatment CLZ microparticles BAC D-Mannitol HPCD MC CLZmicro 1.0 0.001 0.1 5.0 1.0 - - Milled-CLZBAC(-) 1.0 - 0.1 5.0 1.0 Ball mill Bead mill Milled-CLZmannitol(-) 1.0 0.001 - 5.0 1.0 Ball mill Bead mill Milled-CLZHPCD(-) 1.0 0.001 0.1 - 1.0 Ball mill Bead mill Milled-CLZMC(-) 1.0 0.001 0.1 5.0 - Ball mill Bead mill CLZnano 1.0 0.001 0.1 5.0 1.0 Ball mill Bead mill

Table 1:Ophthalmic formulations of particle dispersionscontaining CLZ.