| |
AUCCLZ (nmol•min/g or ml) |
AUMCCLZ(nmol•min2/g or ml) |
MRTCLZ (min) |
| Blood |
CLZmicro |
8.0 ± 2.6 |
237.5 ± 21.9 |
29.6 ± 1.9 |
| |
CLZnano |
11.2 ± 3.4 |
335.3 ± 30.8* |
30.0 ± 2.2 |
| Cornea |
CLZmicro |
80.8 ± 5.6 |
1582.5 ± 105.7 |
19.5 ± 1.1 |
| |
CLZnano |
165.4 ± 10.7* |
3397.5 ± 195.8* |
20.5 ± 1.5 |
| Lens |
CLZmicro |
10.4 ± 1.1 |
264.3 ± 11.9 |
25.3 ± 1.1 |
| |
CLZnano |
18.8 ± 1.6* |
446.1 ± 16.4* |
23.7 ± 0.9 |
| Vitreous body |
CLZmicro |
4.3 ± 0.1 |
103.8 ± 5.4 |
23.9 ± 1.2 |
| |
CLZnano |
46.0 ± 2.9* |
1088.1 ± 67.7* |
23.6 ± 1.0 |
| Sclera and Choroid |
CLZmicro |
1284.4 ± 97.1 |
23625.6 ± 896.8 |
18.4 ± 0.7 |
| |
CLZnano |
6758.1 ± 592.7* |
141975.0 ± 4517.7* |
20.9 ± 1.1 |
| Retina |
CLZmicro |
16.4 ± 0.7 |
418.5 ± 9.3 |
25.6 ± 1.3 |
| |
CLZnano |
149.2 ± 10.8* |
3831.8 ± 182.5* |
26.1 ± 1.0 |
| Anterior part |
CLZmicro |
90.2 ± 9.3 |
2571.0 ± 149.3 |
26.7 ± 1.0 |
| |
CLZnano |
4018.2 ± 294.5* |
101025.8 ± 3927.1* |
25.1 ± 1.1 |
| Posterior part |
CLZmicro |
68.1 ± 3.5 |
2130.7 ± 174.7 |
31.3 ± 1.3 |
| |
CLZnano |
1090.0 ± 70.2* |
31650.1 ± 1298.2* |
29.0 ± 1.4 |
|
| Parameters were calculated according to Eqs. 1-3 (see Materials and methods). CLZCLZmicro, CLZCLZmicro-instilled rats; CLZnano, CLZnano-instilled rats. The data are presented as means ± S.E. of 6 independent rats. *P< 0.05, vs. CLZmicrofor each category. |
| Table 3: Pharmacokinetic parameters for CLZ concentrations after the instillation of CLZCLZmicroor CLZnano in blood and cornea, lens, vitreous body,sclera, choroid,retina,anterior andposterior part of right eye |
