AUCCLZ (nmol•min/g or ml) AUMCCLZ(nmol•min2/g or ml) MRTCLZ (min)
Blood CLZmicro 8.0 ± 2.6 237.5 ± 21.9 29.6 ± 1.9
  CLZnano 11.2 ± 3.4 335.3 ± 30.8* 30.0 ± 2.2
Cornea CLZmicro 80.8 ± 5.6 1582.5 ± 105.7 19.5 ± 1.1
  CLZnano 165.4 ± 10.7* 3397.5 ± 195.8* 20.5 ± 1.5
Lens CLZmicro 10.4 ± 1.1 264.3 ± 11.9 25.3 ± 1.1
  CLZnano 18.8 ± 1.6* 446.1 ± 16.4* 23.7 ± 0.9
Vitreous body CLZmicro 4.3 ± 0.1 103.8 ± 5.4 23.9 ± 1.2
  CLZnano 46.0 ± 2.9* 1088.1 ± 67.7* 23.6 ± 1.0
Sclera and Choroid CLZmicro 1284.4 ± 97.1 23625.6 ± 896.8 18.4 ± 0.7
  CLZnano 6758.1 ± 592.7* 141975.0 ± 4517.7* 20.9 ± 1.1
Retina CLZmicro 16.4 ± 0.7 418.5 ± 9.3 25.6 ± 1.3
  CLZnano 149.2 ± 10.8* 3831.8 ± 182.5* 26.1 ± 1.0
Anterior part CLZmicro 90.2 ± 9.3 2571.0 ± 149.3 26.7 ± 1.0
  CLZnano 4018.2 ± 294.5* 101025.8 ± 3927.1* 25.1 ± 1.1
Posterior part CLZmicro 68.1 ± 3.5 2130.7 ± 174.7 31.3 ± 1.3
  CLZnano 1090.0 ± 70.2* 31650.1 ± 1298.2* 29.0 ± 1.4
Parameters were calculated according to Eqs. 1-3 (see Materials and methods). CLZCLZmicro, CLZCLZmicro-instilled rats; CLZnano, CLZnano-instilled rats. The data are presented as means ± S.E. of 6 independent rats. *P< 0.05, vs. CLZmicrofor each category.
Table 3: Pharmacokinetic parameters for CLZ concentrations after the instillation of CLZCLZmicroor CLZnano in blood and cornea, lens, vitreous body,sclera, choroid,retina,anterior andposterior part of right eye