AUCΔRVC(%•min) AUMCΔRVC (%•min2) MRTΔRVC(min)
Vehicle 181.3 ± 7.9 7623.0 ± 321.5 42.0 ± 0.8
CLZmicro 904.1 ± 31.3*1 61593.7 ± 2286.4*1 68.1 ± 1.1*1
CLZnano 3909.4 ± 117.5*1,2 423018.2 ± 14105.3*1,2 108.2 ± 1.7*1,2
Retinal vasoconstriction in the right eye was caused by intravitreal injection of ET-1. Parameters were calculated according to Eqs. 4-7 (see Materials and methods).Vehicle, vehicle-instilled rats; CLZmicro, CLZmicro-instilled rats; CLZnano, CLZnano-instilled rats. The data are presented as means ± S.E. of 6 independent rats. *1P< 0.05, vs. vehicle for each category. *2P<0.05, vs. CLZmicrofor each category.
Table 4: Pharmacokinetic parameters for thesuppression of retinal vasoconstriction by CLZnano in rats injected intra vitreally with ET-1