Figure 2: siRNA delivery via Wrapsome and inhibition of targetgene expression in inflamed synovia siRNA encapsulatedWrapsome circulates and leaks out into synovial tissue from bloodvessel located in inflamed synovia by EPR effect after intravenouslyadministration. Target gene expressing cell such as macrophageincorporates siRNA encapsulated Wrapsome in synovial tissue.siRNA inhibits target gene expression with RNA interferencepathway.