| Trial |
Main evaluation end-points |
Specific parameters |
| 1 |
Heart rate variability(HRV),arrhythmia |
SDNN, SDANN, SDNNi, rMSSD, TI |
| 2 |
Left ventricular efficiency, hemodynamic measurements |
MVO2, dP/dtmax, SW, dP/dtmax/MVO2, SW/MVO2, heart rate, blood pressure |
| 3 |
Endothelial function, oxidase stress, hemodynamic measurements |
FBF, plasma MDA, blood pressure |
| 4 |
Endothelial function, biochemical parameters |
endothelium-dependent vasodilator capacity,creatinine, heart rate, blood pressure |
| 5 |
Endothelial function,oxidase stress, biochemical parameters |
arms and legs blood flow, allantoin, UA |
| 6 |
BNP, exercise capacity, biochemical parameters |
BNP, 6MWT, cholesterol, UA, creatinine, CRP, blood pressure |
| 7 |
Endothelial function, BNP, biochemical parameters |
FBF, BNP, UA, creatinine, cholesterol, CRP |
| 8 |
Left ventricular function, biochemical parameters |
LVEF, end-systolic and end-diastolic volumes, UA |
| 9 |
Heart remodeling, NT-pro BNP |
MMP-2, MMP-9, TIMP-1, TIMP-2, NT-pro BNP |
| 10 |
Endothelial function, oxidase stress, heart remodeling, exercise capacity |
MDA, ecSOD activity, FDD, MMP-2, MMP-9, TIMP-1, 6MWT, UA |
| 11 |
Left myocardial function, biochemical parameters |
SUA, LVEF, E/A ratio, LVM, Tei index |
| 12 |
Endothelial function, oxidase stress, hemodynamic measurements |
ADMA, FBF, allantoin, UA, heart rate, blood pressure |
| 13 |
Endothelial function, myeloperoxidase(MPO), NT-pro BNP, biochemical parameters |
EPCs, myeloperoxidase(MPO), FMD, NT-pro BNP, UA, CRP, ox-LDL |
| 14 |
Left ventricular function, coronary microvascular function |
LVEF, coronary flow reserve, UA |
| 15 |
Myocardial energy metabolism, hemodynamic measurements |
PCr, PCr/ATP, ADP, CK flux, △G~ATP, heart rate, blood pressure |
| 16 |
NT-proBNP, NYHA functional class, biochemical parameters |
UA, creatinine, eGFR, daily urine output, NT-proBNP, NYHA functional class |
| 17 |
Left ventricular mass, endothelial function |
LV mass, LV mass index, FMD, Alx |
| 18 |
BNP,exercise capacity, biochemical parameters |
time to ST depression, total exercise time, time to chest pain, BNP, UA, Cr, CRP |
| 19 |
Endothelial function, oxidase stress, BNP, biochemical parameters |
FMD, AIx, UA, creatinine clearance, BNP, ox-LDL |
| 6MWT: 6 minute walk test; ADP: adenosine diphosphate; ATP: adenosine triphosphate; ADMA: asymmetric dimethylarginine;Alx: augmentation index; BNP: B-type natriuretic peptide; CK: creatine kinase; dP/dtmax: peak rate of rise of left ventricular pressure; CRP: C reactive protein; ecSOD:extracellular superoxide dismutase; eGFR: estimated glomerular filtration rate; EPCs: Circulating endothelial progenitor cells; FBF: forearm blood flow; FMD: flow-mediated dilation; FDD: flow-dependent endothelial-medicated vasodilation; △G~ATP: free energy of adenosine triphosphate hydrolysis; LVEF: left ventricular ejection fraction; MDA:malondialdehyde; MMPs: matrix metalloproteinases; MVO2:myocardial oxygen consumption; NT-proBNP: N-terminal pro-brain natriuretic peptide; NYHA: New York Heart Association; oxLDL: oxidized low-density lipoprotein; PCr: reatine phosphate; rMSSD, root-mean-square of the successive normal sinus RR interval difference; SDANN, standard deviation of the averaged normal sinus RR intervals for all 5 min segments; SDNN, standard deviation of all normal sinus RR intervals over 24 h; SDNNi, mean of the standard deviations of all normal sinus RR intervals for all 5 min segments; Tei index: left ventricular total isovolumic ejection index; TI, triangular index; SW: stroke work; TIMPs: tissue inhibitors of metalloproteinases; UA: uric acid |
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