Cont DM Amlo Cilni Irbe Irbe + Amlo Irbe + Cilni Number 4 4 4 4 4 4 4 SBP-Pre 97 ± 3 102 ± 3 102 ± 5 106 ± 5 103 ± 3 105 ± 3 104 ± 4 -Post 94 ± 4 100 ± 3 93 ±3 95±2a 94 ± 4a 88 ± 6a 85 ±3a Ccr 0.52 ± 0.05 0.68 ± 0.08b 0.71 ± 0.10b 0.62 ±0.09 0.56 ± 0.05 0.59 ± 0.07 0.53 ± 0.10

Data are expressed as mean ± SEM. aP<0.05 vs. Pre. bP<0.05 vs. Cont. SBP: systolic blood pressure (mmHg); Ccr: creatinine clearance (ml/min-BW 100 g); Cont: non-DM control; DM: diabetic control; Amlo: amlodipine; Cilni: cilnidipine; Irbe: irbesartan.

Table 1: Changes in blood pressure following acute drug administration.