n=27 Marketed & In-house RE assay+ RE assay- Compounds (%)     HLM assay+ 15* (56%) ** 7 (26%) HLM assay- 0* (0%) 5 (18%)

*Number of compounds; **% compound

Table 2: Comparison between recombinant enzyme (RE) MDI assay versus Human liver microsomes (HLM) MDI assay.