Sample Zone of inhibition in millimeters (mm) E.coli S. E. coli R S. aureus TMP 18.5 29.6 22.5 PM 16.0 28.5 20.2 KN 17.0 29.0 19.5 FD 14.0 30.3 26.0 SD 14.0 30.7 26.7

Table 3: Antibacterial activity of trimethoprim (TMP), physical mixture (PM), kneaded (KN), freeze-dried (FD) and spray-dried (SD) systems against bacterial test organism.