Ingredients Batch mg/unit dose A B C D E F G H I AIN 10 10 10 10 10 10 10 10 10 Olive oil 216 216 216 - - - - - - Castor Oil - - - 216 216 216 - - - Soybean Oil - - - - - - 216 216 216 Polyglyceryl-6 octastearate 54 - - 54 - - 54 - - Stearoyl macrogol-32 glycerides - 54 - - 54 - - 54 - Lauroyl macrogol-6 glycerides - - 54 - - 54 - - 54 Total 280 280 280 280 280 280 280 280 280

Table 1: Details of experiments performed for selection of oil and surfactant for alitretinoin lipid formulation.