Case Age Gender Year of death Brain (ng/g) Blood (ng/mL) 6-MAM Mor Cod 6-MAM Mor Cod 1 23 M 2008 <LOD 175.2 23.5 <LOD 33 10 2 24 M 2009 <LOD 165.5 35.4 <LOD 315 73 3 42 M 2009 <LOD 525.5 83.7 <LOD 338 64 4 45 M 2009 <LOD 534.5 44.3 <LOD 688 150 5 36 M 2009 <LOD 149.4 20.6 <LOD 615 193 6 45 M 2009 <LOD 241.5 47.0 <LOD 228 25 7 42 M 2011 <LOD 158.4 23.7 <LOD 130 <LOD 8 35 M 2011 <LOD 132.5 17.7 <LOD 171 <LOD 9 40 F 2012 <LOD 157.4 < LOD <LOD 117 9.1 10 56 M 2013 15.6 273.0 23.3 6.1 265 19.8 11 38 M 2013 20.5 375.2 35.6 <LOD 475 28.8 12 48 M 2013 28.9 246.4 25.4 <LOD 441 29.1 13 35 M 2014 24.6 157.1 20.2 <LOD 192 14.6 14 43 M 2014 <LOD 147.7 10.0 <LOD 78 11.3 15 30 M 2014 20.9 928.6 138.0 <LOD 764 85

Table 1: Overview of the cases studied and concentration of 6-MAM, morphine (Mor) and codeine (Cod) in the brain (ng/g) and in the blood (ng/mL) from STA [11].