Level Voriconazole Impurity A Impurity B Impurity C Impurity D Conc. (μg/mL) Area (μV* sec) Conc. (μg/mL) Area (μV* sec) Conc. (μg/mL) Area (μV* sec) Conc. (μg/mL) Area (μV* sec) Conc. (μg/mL) Area (μV* sec) LOQ 123.6 350 81.3 460 60.8 220 76 210 146.7 246 40% 424 810 432 1780 428 1357 412 1190 436 695 80% 848 1498 864 3240 856 2565 824 2200 872 1295 100% 1060 1790 1080 3920 1070 3120 1030 2650 1090 1570 120% 1272 2096 1296 4640 1284 3750 1236 3190 1308 1820 160% 1696 2769 1728 5995 1712 4954 1648 4176 1744 2380 Slope 1.5271 3.3493 2.8483 2.4975 1.3257 Intercept 173.85 279.40 92.38 93.99 97.75 R 0.9997 0.9994 0.9998 0.9993 0.9990 RRF 1.00 2.19 1.87 1.64 0.87

RRF-Relative Response factor, R- Correlation Coefficient

Table 4: Linearity results.