S.No Lipinski rule of 5 parameters Complex 8 complex 9 1 mi Log P 4.2 3.7 2 TPSA 22.26 24.71 3 HBA 6 2 4 HBD 0 2 5 N0-of rotatable bonds 2 2

1. The log P value calculated using mol inspiration server 2. Topological polar surface area (defined as a sum of surfaces of polar atoms in a molecule) 3. Hydrogen bond acceptor (expressed as the sum of O and N atoms) 4. Hydrogen bond donor (expressed as the sum of OH and NH)

Table 3: Physicochemical properties of the synthesized complex 8 and 9.