S.No Lipinski rule of 5 parameters Complex 8 complex 9
1 mi Log P 4.2 3.7
2 TPSA 22.26 24.71
3 HBA 6 2
4 HBD 0 2
5 N0-of rotatable bonds 2 2
1. The log P value calculated using mol inspiration server
2. Topological polar surface area (defined as a sum of surfaces of polar atoms in a molecule)
3. Hydrogen bond acceptor (expressed as the sum of O and N atoms)
4. Hydrogen bond donor (expressed as the sum of OH and NH)
Table 3: Physicochemical properties of the synthesized complex 8 and 9.