Analyte RRT in LC MS MS-ES or MS-MS m/z value Measured Mass Best possible molecular formulae Exact Mass PPM error AMD-Imp 0.53 MS-ES 157.0247 156.0247 C7H8O2S 156.0245 -1.28       125.0346 124.0346 C7H8S 124.0347 0.81 AMD 1.00 MS-ES 296.0721 273.0823 C15H15NO2S 273.0823 0.00       297.0710 273.0812 C15H15NO2S 273.0823 4.03       274.0828 273.0828 C15H15NO2S 273.0823 -1.83       167.0843 167.0843 C13H11+ 167.0855 7.18       168.0848 167.0848 C13H11+ 167.0855 4.19   1.00 MS-MS 296.0711 273.0813 C15H15NO2S 273.0823 3.66       167.0856 167.0856 C13H11+ 167.0855 -0.60       168.0858 167.0858 C13H11+ 167.0855 -1.80

Table 6: Observed m/z values for the [M + H]+ ions and major fragments of AMD and its impurity in drug.