Formulations Independent variables Concentration of Pectin (X1) Concentration of Eudragit™L100 (X2) F1 -1 -1 F2 0 -1 F3 +1 -1 F4 -1 0 F5 0 0 F6 +1 0 F7 -1 +1 F8 0 +1 F9 +1 +1

X1: Concentration of pectin in compression coating (%), Level: -1 (30), 0 (60), +1 (90) X2: Concentration of Eudragit™ L100 in coating solution (%), Level: -1 (3.5), 0 (8),+1 (12.5)

Table 2: Experimental design using two independent variables with three levels.