Formulations Independent variables
Concentration of Pectin (X1) Concentration of Eudragitâ„¢L100 (X2)
F1 -1 -1
F2 0 -1
F3 +1 -1
F4 -1 0
F5 0 0
F6 +1 0
F7 -1 +1
F8 0 +1
F9 +1 +1
X1: Concentration of pectin in compression coating (%), Level: -1 (30), 0 (60), +1 (90)
X2: Concentration of Eudragitâ„¢ L100 in coating solution (%), Level: -1 (3.5), 0 (8),+1 (12.5)
Table 2: Experimental design using two independent variables with three levels.