Glimepiride Type of stability t (month) Disintegration time( s ) Avarage weight( mg ) Hardness ( kp ) Friability( % ) *Dissolution rate ( % ) Amount(mg/ tablet)
G1 (Measured) Accelerated 0 70.330 85.096 7.000 0.959 84.534 0.878
6 47.220 84.766 6.500 0.460 68.895 0.802
Long term 0 70.330 85.096 7.000 0.960 82.406 0.878
3 50.900 85.766 7.000 0.251 84.259 0.713
6 48.300 84.520 6.500 1.254 80.555 0.792
G2(Calculated) Accelerated 0 109.460 120.000 8.760 0.280 105.140 1.560
6 106.370 120.000 8.220 0.310 96.950 1.430
Long term 0 109.460 120.000 8.760 0.280 105.140 1.560
3 107.270 120.000 8.640 0.440 104.760 1.500
6 105.080 110.000 8.500 0.600 104.380 1.450
G3(Calculated) Accelerated 0 141.610 140.000 10.580 0.180 103.140 2.610
6 138.520 140.000 10.030 0.220 94.950 2.490
Long term 0 141.610 140.000 10.580 0.180 103.140 2.610
3 139.420 140.000 10.450 0.540 102.760 2.550
6 137.220 140.000 10.320 0.300 102.380 2.500
G4 (Measured) Accelerated 0 150.330 167.066 13.000 0.172 85.494 3.882
6 164.900 167.300 12.000 0.422 83.178 3.690
Long term 0 150.500 167.066 13.000 0.188 85.494 3.910
3 166.300 167.133 11.500 0.213 85.340 3.813
6 162.30 166.80 12.5 0.531 84.260 3.765
** correlation coefficiency ( r2)     0.9804 0.9996 0.9832 0.4085 0.5938 0.9986
***F(calculated)     238.079 12086.627 423.224 3.280 6.943 3288.504
p     0.000 0.000 0.000 0.033 0.001 0.000
*amount of active substance released at 15 minute
**correlation coefficient values of all quality control parameters.
*** F: Degrees of freedom
Table 6: Statistical stability results of bracketing design.