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| Table 1: The effect of leech saliva extract on the cytotoxic activity of Irinotecan and Carboplatin in SW1271 cell line SW1217 was treated by a serial double dilution of LSE combined with Irinotecan/Carboplatin. Cell viability was determined by CellTiter-Glo® luminescent cell viability assay after 5days of incubation. It was found that LSE enhanced the cytotoxic activity of Carboplatin. Whereas, Irinotecan enhanced the antiproliferative activity of LSE. | ||||||||||||||||||||||||