Formulation code Penetration  Flux J (µgcm−2 h−1) Lag time (h) Permeability coefficient Kp ×102 (cm h−1) Enhancement ratio** Correlation coefficient R2 F1, 1:1 22.608±3.45* 1.6±0.15 0.22±0.0003 8.939 0.9978 F2, 2;1 16.278±1.36* 2.2±0.23 0.16±0.0001 6.436 0.9938 F3, 3:1 11.819±3.56* 3.0±0.45 0.11±0.0003 4.673 0.9956 F4, 4:1 10.736±2.69* 3.5±0.32 0.10±0.0002 4.245 0.9877 F5, 1:2 12.355±1.05* 4.0±0.37 0.12±0.0001 4.885 0.9878 F6, 3:2 18.764±5.72* 2.0±0.28 0.18±0.0005 7.419 0.9974 Commercial IND gel (1%) 2.529±1.09 4.5±0.27 0.02±0.0001 --   *Means P <0.0001 compared with the commercial IND gel ** Enhancement ratio compared with the commercial IND gel

Table 4: Penetration flux, lag time, permeability coefficient, enhancement ratio and correlation coefficient of regression analysis of release data according to Zero order model.