# R R’ X Product nmol of MDA (TBARS)
Control (0) 1 5 10 50 100
C-1 Ph Ph Br 542± 21 538±22 540±23 563±22 523±12 511±21 a
C-2 Ph PhCH2 Cl 542±19 549±19 550±21 564±31 526±19 509 ±12 a
C-3 o-MeOC6H4 PhCH2 Cl 542±19 541±21 559±12 547±18 535±21 443 ±23 b
C-4 p-MeOC6H4 PhCH2 Cl 542±34 511±15 523±28 565±18 484±22 307 ±32 c
C-5 o-MeC6H4 PhCH2 Cl 542±12 547±23 548±32 534±32 548±32 469 ±13 b
C-6 p-MeC6H4 PhCH2 Cl 542±21 561±12 545±31 555±21 507±12 348 ±23 c
C-7 Ph o-MeC6H4CH2 Br 542±23 541±31 551±12 533±12 496±12 440 ±21 b
C-8 Ph m-MeC6H4CH2 Br 542±32 551±23 568±17 546±23 498±18 459 ±14 b
C-9 Ph p-MeC6H4CH2 Br 542±12 527±24 536±16 541±31 482±21 448 ±31 b
C-10 p-ClC6H4 PhCH2 Cl 542±32 736±21 701±32 730±18 746±23 780 ±22 e
Table 1: Synthesis pattern and effects of different oraganochalgens on TBARS production in rat’s brain preparation. TBARS are expressed as nmol of MDA/g of tissue. Data are presented as mean ± S.E.M. (n = 5). Different letters represent significant difference as compared with C-1.