Figure 2: Antidepressant-like effect of E2 in OVX CD-1 mice (n=12) observed at various time points (24 h: Day 1; 48 h: Day 2; 96 h: Day 4; 192 h: Day 8) after a single i.v. dose of 300 μg/kg E2-CDS (as HPBCD inclusion complex). Control animals received vehicle only. *Significant difference compared with control (ANOVA analysis followed by post hoc Dunnett test; p<0.05).