Formulation Code Polymers blend (% w/w) Drug level (g) Cross-linking agent/level (% w/v) Curing time (min) Stirring Speed (rpm) F1 Sodium alginate, 1% + Guar Gum, 1% 1 CaCl2, 5% 30 1000 F2 Sodium alginate, 1% + Guar Gum, 2% 1 CaCl2, 5% 30 1000 F3 Sodium alginate, 1% + Guar Gum, 3% 1 CaCl2, 5% 30 1000 F4 Sodium alginate, 1% + Guar Gum, 4% 1 CaCl2, 5% 30 1000 F5 Sodium alginate, 1% + Guar Gum, 5% 1 CaCl2, 5% 30 1000 F6 Sodium alginate, 1% + Guar Gum, 6% 1 CaCl2, 5% 30 1000

Table 1: Composition of losartan potassium loaded of algino-guar micro matrix system.