Models Formulation Zero order R2 First order R2 Higuchi R2 Korsmeyer-Peppas      R2                   n F1 0.839 0.989 0.982 0.991 0.414 F2 0.881 0.992 0.993 0.996 0.442 F3 0.912 0.980 0.991 0.995 0.445 F4 0.943 0.975 0.993 0.997 0.436 F5 0.977 0.992 0.985 0.999 0.419 F6 0.988 0.992 0.970 0.998 0.446

Table 3: In vitro kinetic model fitting.