Models Formulation Zero order
R2
First order
R2
Higuchi
R2
Korsmeyer-Peppas
     R2                   n
F1 0.839 0.989 0.982 0.991 0.414
F2 0.881 0.992 0.993 0.996 0.442
F3 0.912 0.980 0.991 0.995 0.445
F4 0.943 0.975 0.993 0.997 0.436
F5 0.977 0.992 0.985 0.999 0.419
F6 0.988 0.992 0.970 0.998 0.446
Table 3: In vitro kinetic model fitting.