Unstandardized Parameter Estimate (95% CI)

 

Outcome Variables (Unadjusted)

Outcome Variables (Adjusted)

Predictor Variables

BDI-II Depressiona

HAM-D Depressiona

Proportion Illicit Drug Use Days

BDI-II Depressiona

HAM-D Depressiona

Proportion Illicit Drug Use Days

Intercept

2.15 (1.82, 2. 47)

1.90 (1.63, 2.18)

0.27 (0.16, 0.38)

2.11 (1.79, 2.43)

1.88 (1.60, 2.15)

0.16 (-0.02, 0.34)b
0.03 (-0.15, 0.21)c

Linear Slope Baseline -6 months

-0.01 (-0.15, 0.13)

0.02 (-0.09, 0.14)

-0.004 (-0.05, 0.04)

-0.02 (-0.15, 0.10)

0.01 (-0.09, 0.12)

-0.003 (-0.05, 0.04)b -0.01 (-0.05, 0.04)c

Baseline Treatment Difference

0.27 (-0.20, 0.74)

0.34* (-0.06, 0.75)

-0.13 (-0.29, 0.04)

0.16 (-0.31, 0.63)

0.27(-0.13, 0.67)

-0.14* (-0.30, 0.02)b -0.17* (-0.33, -0.02)c

Treatment Difference in Linear Slope Baseline–6 months

-0.12 (-0.32, 0.09)

-0.09 (-0.26, 0.08)

0.01 (-0.06, 0.08)

-0.12 (-0.31 0.07)

-0.09 (-0.25, 0.06)

0.02 (-0.05, 0.09)b
0.02 (-0.05, 0.09)c

Note: Adjusted parameter estimates control for time-varying antidepressant use for BDI-II and HAM-D outcomes, and for time-varying BDI-IIb and HAM-Dc for the illicit drug use outcome. a log transformed. * p<0.10
Table 3: Random Effects Regression Results for Repeated Primary Outcome Measures.
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