Drug of Abuse Measure Outcome Comment Reference
Alcohol qEEG and LORETA mapping Increase in absolute and relative beta power and a decrease in alpha and delta/theta power. Detoxified patients compared to normal controls Saletu et al.[.5]
Alcohol EEG Subjects with family history have reduced relative and absolute alpha power in occipital and frontal  regions and increased relative beta in both regions. Family history of alcoholism compared no family history Finn and Justus [6]
Alcohol EEG Alcoholics differ in resting EEG coherence having lower frontal alpha and slow –beta coherence in males and females. Heavy drinkers compared to light drinkers Kaplan et al. [7]
Alcohol EEG In alcohol –dependent subjects found higher central alpha and slow –beta coherence, but lower parietal alpha and slow –beta coherence in males. Alcohol -dependent compared to controls Michael et al.[8]
Alcohol EEG Higher left-temporal alpha and slow beta coherence and higher slow-beta coherence at right –temporal and frontal  electrode pairs in alcoholic males and females. Alcohol -dependent compared to controls Winterer et al. [9]
Alcohol EEG Moderate to heavy drinking is associated with differences in synchronization of brain activity during rest and mental rehearsal.  Heavy drinkers displayed  a loss of hemispheric asymmetry of EEG synchronization in the alpha and slow –beta band. Moderately and heavy drinking males also showed lower fast-beta band synchronization.  Comparison of moderate –heavy  to Heavy drinking De Bruin et al. [10]
Marijuana EEG Acute THC exposure produced  transient increases in either posterior alpha power, decreases in mean alpha frequency or increase in alpha synchrony and  decrease in relative power of beta. Acute effects of  THC Struve et al. [11]
Marijuana qEEG Significant association between chronic marijuana  use and  topographic qEEG patterns of persistent “ alpha hyperfrontality” as well as reductions in alpha mean frequency. There was also elevated voltage  of all non-alpha bands in chronic marijuana users.  Finally  there was  a widespread decrease in the  relative power of delta and beta activity over the frontal cortical regions in chronic  marijuana users. Chronic effects of THC exposure. Struve et al. [12]
Heroin qEEG Qualitative changes  were observed in  more than 70%  of heroin addicts in early abstinence and included  low-voltage background activity with diminution of alpha rhythm , an increase in beta activity , and a large amount of low amplitude delta and theta waves in central regions.  Also frequency shifts in fast alpha range at the frontal and central recording sites and a slowing of slow wave alpha mean frequency at the central, temporal, and occipital sites  of recording heroin  abusers who used heroin for at least 18 months. Acute withdrawal Polunia and Davydov  et al. 13]
Heroin qEEG Abstinent alcoholics have an enhanced  fast beta power compared to healthy controls. Alcoholics compared to healthy controls Franken et al. [14]
Heroin EEG Elevated synchrony within beta frequency during short term  heroin withdrawal  may reflect  a state of CNS  activation toward reward –seeking behavior, with this being a prerequisite to relapse among opiate  drug dependent patients. Polydrug abusers  with emphasis on heroin abuse. Bauer et al. [15]
Cocaine EEG Acute  effects of cocaine  include increase in beta activity, increase in delta,  increase in frontal alpha as well  as an increase in alpha wave EEG  associated with bursts of cocaine –induce euphoria.  Human studies Prichep et al. [16] Alper[17]
Cocaine qEEG During protracted abstinence from cocaine qEEG effects include long-lasted increases in  alpha and beta bands together  with reduced activity in delta and theta bands. Several studies  reported similar effects on withdrawal. Roemer et al. [18]
Cocaine qEEG Cocaine produced a rapid increase in absolute theta, alpha and beta power over the prefrontal cortex, up  to 25 minutes  after  drug administration. The increase in theta power was correlated with a positive drug high, and the increase in alpha power was correlated with anxiety. Also an increase in delta coherence over the prefrontal cortex correlated with nervous energy. qEEG profiles in cocaine-dependent patients in response to an acute, single-blind, self –administered dose of smoked  cocaine base (50 mg) versus placebo. Reid et al. [19]
Cocaine qEEG Changes  occur 5-14 days after last reported crack cocaine use  induced  changes in brain function. These changes lasted  up to six months. Subjects with cocaine dependence  have persistent  changes in brain function Venneman et al. [20]
Cocaine qEEG qEEG techniques demonstrate  an association   between beta  activity in the spontaneous EEG  and relapse in cocaine abuse. qEEG changes  associate with relapse  Ceballos et al. [21]
Source: Miller et al. Post Graduate Medicine (in press) with permission.
Table 1: QEEG, EEG changes in Substance Abuse.