| People at Risk of Opioid Overdose may be defined as people who use opioids and also meet one or more of the following criteria: |
| • Known or suspected prescription opioid dependence or heroin use [30] |
| • History of emergency care for opioid overdose [31] |
| • Opioid use with known or suspected use of alcohol or benzodiazepines, or other drugs known to increase overdose risk [32,33] |
| • Release from prison with a history of opioid dependence [34] |
| • Discharge from a treatment program for opioid dependence [35] |
| •Enrollment in opioid dependence treatment with methadone during specific times such as induction or discharge [36,37] |
| • High doses of prescribed opioids [38] |
