5 min 15 min 30 min 45 min 90 min   Male Female Male Female Male Female Male Female Male Female p-PKA substrate 24.5 ± 11.9 136.8 ± 38.7* 89.1 ± 33.8 77.7 ± 38.9 53.2 ± 31.6 144.3 ± 13.5* 41.2 ± 27.3 54.5 ± 24.7 -3.3 ± 22.2 74.4 ± 47.4 p-ERK 173.2 ± 34.9 231.4 ± 43.7 129.8 ± 4.6 155.6 ± 36.2 164.6 ± 19.3 207.0 ± 28.5 96.8 ± 15.1 100.3 ± 12.1 112.7 ± 15.5 94.2 ± 22.7

Data are presented as % change of protein levels ± SEM as compared to 5 min saline controls of the same sex. * And bolded represents statistically significant differences between sexes. (N = 4 per group).

Table 1: Percentage change of p-(Ser/Thr)-PKA- substrate signaling and p-ERK protein levels in NAc.