Figure 4: Effects of repeated (10 days) treatment with disulfiram (DSF; 25, 50 and 100 mg /kg/day, sc) on naloxone (1 mg/kg, sc) precipitated withdrawal jumps following administration of methadone (48 mg/kg/day sc, for 10 days) in mice. Data are presented as the mean ± SEM. N=10 mice/group.
* p<0.05, ** p<0.01 DSF+methadone vs. methadone+vehicle, the one-way repeated-measures analysis of variance (ANOVA) and Bonferroni test.